Secondary Chloride-losing Diarrhoea

Secondary chloride-losing diarrhoea. Observations on stool electrolytes in infants after bowel surgery.

Aaronson, I. (1971). Archives of Disease in Childhood, 46, 479. Secondary chloride-losing diarrhoea. Observations on stool electrolytes in infants after bowel surgery. Among 40 infants with postoperative diarrhoea, 3 were found to have a stool chloride concentration in excess of the sum of sodium and potassium ion concentrations. All 3 had had a recent episodof intestinal obstruction and had de...

Chloride losing diarrhoea and metabolic alkalosis in an infant with cystic fibrosis.

A case of hypochloraemic metabolic alkalosis in an infant with chloride losing ileostomy drainage and cystic fibrosis is described. It is speculated that intestinal loss of chloride played a major role in the development of metabolic alkalosis.

Congenital chloride losing diarrhoea.

Faecal excretion of alpha-1-antitrypsin in acute diarrhoea.

High levels of faecal alpha-1-antitrypsin were found in children suffering from acute rotavirus diarrhoea and in children with diarrhoea in whom no microbial pathogen could be established. The results suggest that transient protein-losing enteropathy is common in acute childhood diarrhoea and may influence the outcome of the disease.

Congenital chloride diarrhoea.

Congenital chloride diarrhoea is an autosomal recessive disease characterized by life-long watery diarrhoea of prenatal onset with high faecal Cl- concentration. Seventy-nine patients have so far been reported. The basic defect involves the active Cl-/HCO3- exchange mechanism of the distal ileum and colon. The defect causes impaired absorption of Cl-, acidity of intestinal contents because of i...